Michael J Ackerman Selected Research

triadin

1/2020	Triadin Knockout Syndrome Is Absent in a Multi-Center Molecular Autopsy Cohort of Sudden Infant Death Syndrome and Sudden Unexplained Death in the Young and Is Extremely Rare in the General Population.
1/2020	Phenotype-guided whole genome analysis in a patient with genetically elusive long QT syndrome yields a novel TRDN-encoded triadin pathogenetic substrate for triadin knockout syndrome and reveals a novel primate-specific cardiac TRDN transcript.
1/2019	International Triadin Knockout Syndrome Registry.
3/2017	Congenital myopathy associated with the triadin knockout syndrome.
6/2015	Homozygous/Compound Heterozygous Triadin Mutations Associated With Autosomal-Recessive Long-QT Syndrome and Pediatric Sudden Cardiac Arrest: Elucidation of the Triadin Knockout Syndrome.

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Michael J Ackerman Research Topics

Disease

120	Long QT Syndrome 10/2022 - 03/2002
43	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 10/2021 - 03/2002
38	Cardiac Arrhythmias (Arrythmia) 10/2021 - 08/2002
33	Cardiac Sudden Death (Sudden Cardiac Arrest) 10/2022 - 03/2002
29	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 01/2003
27	Polymorphic catecholergic ventricular tachycardia 01/2022 - 11/2004
22	Heart Arrest (Cardiac Arrest) 02/2021 - 01/2003
22	Sudden Infant Death (SID) 01/2020 - 06/2004
20	Channelopathies 01/2020 - 08/2002
19	Cardiomyopathies (Cardiomyopathy) 05/2022 - 02/2006
18	Syncope (Fainting) 10/2022 - 01/2003
18	Ventricular Fibrillation 05/2022 - 11/2002
18	Sudden Death 01/2022 - 06/2002
17	Brugada Syndrome 01/2020 - 08/2002
13	Torsades de Pointes (Torsade de Pointes) 01/2022 - 01/2005
12	Ventricular Tachycardia 01/2022 - 05/2002
9	Heart Diseases (Heart Disease) 10/2021 - 03/2002
8	Atrial Fibrillation 01/2022 - 03/2008
8	Cardiomegaly (Heart Hypertrophy) 11/2019 - 08/2005
7	Seizures (Absence Seizure) 10/2022 - 08/2013
7	Shock 01/2022 - 11/2010
7	Hypertrophy 01/2021 - 06/2005
7	Heart Failure 03/2019 - 08/2005
6	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2019 - 10/2005
5	COVID-19 03/2021 - 01/2020
5	Bradycardia 01/2019 - 07/2003
4	Stroke (Strokes) 03/2016 - 10/2008
3	Ventricular Premature Complexes (Premature Ventricular Contraction) 05/2022 - 01/2013
3	Acidosis 01/2022 - 05/2011
3	Infections 03/2021 - 03/2002
3	Fibrosis (Cirrhosis) 01/2021 - 09/2009
3	Inflammation (Inflammations) 01/2020 - 04/2007
3	Hypoglycemia (Reactive Hypoglycemia) 01/2018 - 04/2007
3	Transient Ischemic Attack 03/2016 - 09/2013
3	Andersen Syndrome 10/2009 - 10/2004
2	Tricuspid Valve Insufficiency (Insufficiency, Tricuspid Valve) 01/2022 - 01/2016
2	Postoperative Nausea and Vomiting (PONV) 01/2022 - 02/2013
2	Coronary Artery Disease (Coronary Atherosclerosis) 01/2022 - 01/2016
2	Vascular Diseases (Vascular Disease) 01/2021 - 01/2019
2	Rare Diseases (Rare Disease) 01/2020 - 11/2007
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2020 - 01/2017
2	Congenital Heart Defects (Congenital Heart Defect) 07/2019 - 11/2018
2	Arrhythmogenic Right Ventricular Dysplasia (Arrhythmogenic Right Ventricular Cardiomyopathy) 11/2018 - 01/2016
2	Noonan Syndrome (Female Pseudo-Turner Syndrome) 01/2017 - 08/2007
2	Timothy syndrome 12/2016 - 10/2016
2	Syndactyly (Polysyndactyly) 10/2016 - 06/2013

Drug/Important Bio-Agent (IBA)

39	Proteins (Proteins, Gene)FDA Link 11/2020 - 05/2005
26	Sodium Channels (Sodium Channel)IBA 10/2020 - 08/2002
25	Ion Channels (Ion Channel)IBA 01/2022 - 01/2005
24	DNA (Deoxyribonucleic Acid)IBA 11/2014 - 03/2003
22	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2022 - 10/2004
12	Pharmaceutical PreparationsIBA 01/2022 - 08/2002
12	Potassium Channels (Potassium Channel)IBA 01/2022 - 12/2002
11	CalciumIBA 12/2021 - 06/2007
11	SodiumIBA 01/2020 - 08/2002
6	Caveolin 3IBA 11/2020 - 11/2006
6	Ventricular MyosinsIBA 10/2020 - 06/2002
6	Epinephrine (Adrenaline)FDA LinkGeneric 10/2016 - 05/2002
5	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/2022 - 01/2020
5	triadinIBA 01/2020 - 06/2015
5	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 01/2019 - 06/2013
5	junctophilinIBA 02/2017 - 06/2007
5	Ether (Diethyl Ether)IBA 12/2012 - 12/2002
5	TropomyosinIBA 02/2011 - 12/2002
4	KCNQ1 Potassium ChannelIBA 01/2022 - 03/2012
4	Biological ProductsIBA 12/2021 - 12/2009
4	Azithromycin (Zithromax)FDA LinkGeneric 03/2021 - 09/2013
4	Mexiletine (Mexitil)FDA LinkGeneric 01/2019 - 08/2002
4	Biomarkers (Surrogate Marker)IBA 01/2018 - 12/2013
4	Troponin CIBA 10/2015 - 08/2008
3	Sodium Channel BlockersIBA 10/2022 - 01/2019
3	ElectrolytesIBA 03/2019 - 09/2011
3	NucleotidesIBA 01/2019 - 10/2012
3	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2019 - 01/2016
3	Adrenergic Agents (Adrenergic Drugs)IBA 06/2012 - 10/2009
3	Troponin T (Troponin T1)IBA 08/2008 - 06/2002
3	metavinculinIBA 10/2006 - 02/2006
2	Polyvinyl Chloride (PVC)IBA 05/2022 - 01/2013
2	Cadherins (E-Cadherin)IBA 01/2021 - 03/2017
2	AutoantibodiesIBA 01/2020 - 11/2018
2	Anti-Arrhythmia AgentsIBA 01/2020 - 01/2015
2	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2020 - 11/2005
2	Myosin Light Chains (Myosin Essential Light Chain)IBA 10/2019 - 07/2008
2	dofetilide (Tikosyn)FDA Link 03/2019 - 01/2018
2	PotassiumIBA 01/2019 - 05/2012
2	Phosphotransferases (Kinase)IBA 01/2019 - 06/2007
2	Troponin IIBA 01/2019 - 12/2015
2	EnzymesIBA 01/2019 - 04/2007
2	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2018 - 08/2007
2	Voltage-Gated Sodium ChannelsIBA 01/2018 - 06/2014
2	ParaffinIBA 12/2017 - 01/2012
2	Adenosine Triphosphate (ATP)IBA 01/2017 - 10/2011

Therapy/Procedure

53	Therapeutics 10/2022 - 03/2004
36	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 10/2022 - 03/2002
22	Sympathectomy (Sympathectomies) 10/2022 - 06/2009
8	Defibrillators (Defibrillator) 10/2018 - 11/2002
5	Secondary Prevention 04/2013 - 03/2002
4	Precision Medicine 01/2021 - 04/2013
4	Drug Therapy (Chemotherapy) 01/2020 - 03/2008
4	Genomic Medicine 01/2017 - 05/2005